The Canadian Sphynx is recognized by cat fancy associations as being a healthy robust breed. Lack of hair can cause health issues with kittens in the first weeks of life due to susceptibility to respiratory infections. Reputable breeders will not let their kittens go to new homes without being at least 12 weeks of age to ensure the kitten is mature enough to cope in a new environment. Due to their lack of protective fur, skin cancer may be a problem if exposed to sunlight for long durations of time.
The breed does have instances of the genetic disorder hypertrophic cardiomyopathy. Studies are being undertaken to understand the links in breeding and the disorder.
Sphynx cats can catch common feline diseases and should be immunized in the same way as other breeds.